It depends on what you mean by "fail". A camera sensor that "fails" generally means it is "dead", i.e. non-functional. I have a lens that has had the autofocus electronics and focus motor fail in that manner and it had to be returned to the manufacturer for repairs.
The other view of "fail" is when we try to use it outside of the parameters it is designed to work under. There are two distinct issues here:
1. If the subject not well illuminated or does not have enough contrast, the autofocus mechanism cannot lock focus. Here we are trying to get the camera to work outside of what it was designed to do, and we will not get a focused result.
2. Issues resolving the focus point - we have a number (one or more) points in the viewfinder that the camera uses as focus points. If these are not chosen correctly, the camera may focus on the wrong points and even though it is working properly, it will not be what the end user wanted. I find this is more of an issue when shooting with a long lens at a narrow depth of field. I suspect closeups of flowers would have the same issue.