Canon designers have taken steps to ensure it is physically impossible to mount EF-S lenses on EF-only cameras. This is because the increased proximity of the lens to the sensor means that on full-frame sensor or 35mm film EF cameras the lens itself would obstruct the mirror's movement and cause damage to the lens and/or camera. While it is possible to modify the lens such that the physical obstruction is removed, allowing for mounting to EF mount cameras, the rear of the lens would still obstruct the mirror. An additional reason is that the lenses produce a smaller image circle of even illumination (circle of no vignetting). To assist the photographer, an EF-S lens alignment mark is indicated by a small white rectangle, whereas the EF lenses and mounts use a small red dot. EF-S camera bodies have both EF-S and EF alignment marks, while EF bodies have only EF marks. Some have reported success attaching EF-S lenses to full-frame bodies with the use of an extension tube; however, this does not eliminate the vignetting problem, and also removes the lens's ability to achieve infinite focus. 
The 10D, D60, and earlier cameras share the EF-only mount with the full frame EOS camera bodies, and also with the APS-H size EOS camera bodies (1D series), despite having a smaller sensor and therefore a smaller mirror. However, attempting this on full frame Canon EF mount cameras would cause the mirror to collide with the rear lens element, potentially damaging the lens and/or camera.