I'm also a relative novice at printing. However, you might want to check out
this. The end suggests that in some cases, you would want to downsample for small prints. (Read the very end, along with the attached graphic).
I've avoided all of this by printing from Lightroom's print module, which takes care of this. All you have to do is specify the DPI you want for the printer and the print size. As long as there are enough pixels, it does the rest for you. So far, printing mostly 8*10 (~A4) and smaller, the results have been very good.